COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics
Identifieur interne : 000277 ( Main/Exploration ); précédent : 000276; suivant : 000278COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics
Auteurs : Kuldeep Dhama [Inde] ; Khan Sharun [Inde] ; Ruchi Tiwari [Inde] ; Maryam Dadar [Iran] ; Yashpal Singh Malik [Inde] ; Karam Pal Singh [Inde] ; Wanpen Chaicumpa [Thaïlande]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2020.
Abstract
The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in
Url:
DOI: 10.1080/21645515.2020.1735227
PubMed: 32186952
PubMed Central: 7103671
Affiliations:
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nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharun, Khan" sort="Sharun, Khan" uniqKey="Sharun K" first="Khan" last="Sharun">Khan Sharun</name><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Division of Surgery, ICAR-Indian Veterinary Research Institute</institution>, Bareilly,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tiwari, Ruchi" sort="Tiwari, Ruchi" uniqKey="Tiwari R" first="Ruchi" last="Tiwari">Ruchi Tiwari</name><affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU)</institution>, Mathura,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dadar, Maryam" sort="Dadar, Maryam" uniqKey="Dadar M" first="Maryam" last="Dadar">Maryam Dadar</name><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO)</institution>, Karaj,<country>Iran</country></nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Malik, Yashpal Singh" sort="Malik, Yashpal Singh" uniqKey="Malik Y" first="Yashpal Singh" last="Malik">Yashpal Singh Malik</name><affiliation wicri:level="1"><nlm:aff id="AFF0005"><institution>Division of Biological Standardization, ICAR-Indian Veterinary Research Institute</institution>, Bareilly,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Singh, Karam Pal" sort="Singh, Karam Pal" uniqKey="Singh K" first="Karam Pal" last="Singh">Karam Pal Singh</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Division of Pathology, ICAR-Indian Veterinary Research Institute</institution>, Bareilly,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chaicumpa, Wanpen" sort="Chaicumpa, Wanpen" uniqKey="Chaicumpa W" first="Wanpen" last="Chaicumpa">Wanpen Chaicumpa</name><affiliation wicri:level="1"><nlm:aff id="AFF0006"><institution>Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University</institution>, Bangkok,<country>Thailand</country></nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Vaccines & Immunotherapeutics</title><idno type="ISSN">2164-5515</idno><idno type="eISSN">2164-554X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in <italic>in vitro</italic> studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gulyaeva, Aa" uniqKey="Gulyaeva A">AA Gulyaeva</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Leontovich, Am" uniqKey="Leontovich A">AM Leontovich</name></author><author><name sortKey="Neuman, Bw" uniqKey="Neuman B">BW Neuman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, H" uniqKey="Lu H">H. 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uniqKey="Malik Y" first="Yashpal Singh" last="Malik">Yashpal Singh Malik</name><name sortKey="Sharun, Khan" sort="Sharun, Khan" uniqKey="Sharun K" first="Khan" last="Sharun">Khan Sharun</name><name sortKey="Singh, Karam Pal" sort="Singh, Karam Pal" uniqKey="Singh K" first="Karam Pal" last="Singh">Karam Pal Singh</name><name sortKey="Tiwari, Ruchi" sort="Tiwari, Ruchi" uniqKey="Tiwari R" first="Ruchi" last="Tiwari">Ruchi Tiwari</name></country><country name="Iran"><noRegion><name sortKey="Dadar, Maryam" sort="Dadar, Maryam" uniqKey="Dadar M" first="Maryam" last="Dadar">Maryam Dadar</name></noRegion></country><country name="Thaïlande"><noRegion><name sortKey="Chaicumpa, Wanpen" sort="Chaicumpa, Wanpen" uniqKey="Chaicumpa W" first="Wanpen" last="Chaicumpa">Wanpen Chaicumpa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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